The use of autologous bone flap for cranioplasty after decompressive craniectomy is a widely used strategy that allows alleviating health expenses. When the patient has recovered from the primary insult, the cranioplasty restores protection and cosmesis, recovering fluid dynamics and improving neurological status. During this time, the bone flap must be stored, but there is a lack of standardization of tissue banking practices for this aim. In this work, we have reviewed the literature on tissue processing and storage practices. Most of the published articles are focused from a strictly clinical and surgical point of view, paying less attention to issues related to tissue manipulation. When bone resorption is avoided and the risk of infection is controlled, the autograft represents the most efficient choice, with the lowest risk of complication. Otherwise, depending on the degree of involvement, the patient may have to undergo new surgery, assuming further risks and higher healthcare costs. Therefore, tissue banks must implement protocols to provide products with the highest possible clinical effectiveness, without compromising safety. With a centralised management of tissue banking practices there may be a more uniform approach, thus facilitating the standardization of procedures and guidelines.

Autologous bone flap; Bone infection; Bone resorption; Cranioplasty; Decompressive craniectomy; Storage; Tissue banking.

Vicente Mirabet 1, Daniel García 2, Nuria Yagüe 3, Luis Roberto Larrea 3, Cristina Arbona 3, Carlos Botella 2

1.Cell and Tissue Bank, Centro de Transfusión de la Comunidad Valenciana, Valencia, Spain. mirabet_vic@gva.es. 2.Service of Neurosurgery, Hospital Universitario y Politécnico La Fe, Valencia, Spain. 3.Cell and Tissue Bank, Centro de Transfusión de la Comunidad Valenciana, Valencia, Spain.

Cell Tissue Bank

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2021

自体颅骨

33423107

10.1007/s10561-020-09897-2